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Not choosing sides and no disrespect, but a .22-250 is perfectly adequate for wolves or cougar. Neither are typically difficult to put down with a well placed shot. Both are thin skinned and fragile especially in the rib cage.
Most ranchers and folks I help who deal with wolves and cougars regularly use a .22 center fire. I carry a .233 Sako with 60 grain Barnes TSX, when quad riding on land where predation might occur. Obviously big game hunters who encounter either are typically armed with a larger center fire, but wouldn’t be necessary to dispatch either.
Best of luck. I have mild custom A7 mountain rifle but not in .22-250.Thank you Sean. I have shot both and had great results. Just moving to the 60 grain np as long as it stabilizes as I have a pacemaker now and want to minimize recoil.
Well, it is true that individual rifles may shoot more or less accurately with a given bullet, but this may be due to factors other than twist. One A7 (or L579 or Rem 700) in .22-250 may shoot a particular bullet better than another rifle which is otherwise identical. So no, regardless of whether the 60 grain Noslers I've used were shot through an A7 or some other rifle with a 1-14 twist I can only tell you that the twist is not an issue, not whether that particular bullet/load will shoot well in your particular rifle.From googling I learned it depends on the rifle as well as the twist. You shot it in an a7?